Familial Defective Apolipoprotein B-100 and Increased Low-Density Lipoprotein Cholesterol and Coronary Artery Calcification in the Old Order Amish
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چکیده
منابع مشابه
Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.
BACKGROUND Elevated low-density lipoprotein cholesterol (LDL-C) levels are a major cardiovascular disease risk factor. Genetic factors are an important determinant of LDL-C levels. METHODS To identify single nucleotide polymorphisms associated with LDL-C and subclinical coronary atherosclerosis, we performed a genome-wide association study of LDL-C in 841 asymptomatic Amish individuals aged 2...
متن کاملThe association between small dense low density lipoprotein,apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis
Abstract Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the coronary artery disease (CAD).Small dense LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity...
متن کاملthe association between small dense low density lipoprotein,apolipoprotein b, apolipoprotein b/apolipoprotein a1 ratio and coronary artery stenosis
abstract background: recently, small dense low density lipoprotein (sdldl) has been highlighted as a new risk factor for the coronary artery disease (cad).small dense ldls are believed to be atherogenic since these particles are taken up more easily by arterial wall. they are readily oxidized and have reduced affinity for low density lipoprotein (ldl) receptor and increased affinity for arter...
متن کاملClinical signs of familial hypercholesterolemia in patients with familial defective apolipoprotein B-100 and normal low density lipoprotein receptor function.
In a previous study (Tybjaerg-Hansen et al, Atherosclerosis 1990;80:235-242), we identified nine patients heterozygous for the apolipoprotein B (apo B) arginine-to-glutamine (Arg3,500----Gln) mutation (familial defective apolipoprotein B-100 [FDB]). Six of these had been diagnosed clinically as familial hypercholesterolemic (FH) heterozygotes. We have since examined low density lipoprotein (LDL...
متن کاملDeterminants of coronary artery and aortic calcification in the Old Order Amish.
BACKGROUND Coronary artery calcification (CAC) is associated with an increased risk of cardiovascular disease; little is known, however, about thoracic aortic calcification (AC). Our goal was to characterize risk factors for CAC and AC and to estimate the genetic contribution to their variation. METHODS AND RESULTS The presence and quantity of CAC and AC were measured with electron beam compu...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 2010
ISSN: 0003-9926
DOI: 10.1001/archinternmed.2010.384